Key result
Hypertension was associated with a significantly higher renal atrophic index compared to healthy controls (0.71 vs 0.63, p < 0.001), which correlated with markers of reduced renal function.
Why the study?
Hypertension causes structural and functional renal damage, but the utility of combining renal resistive index with the atrophic index in hypertensive patients with normal renal function required evaluation.
Does the sonographic atrophic index (AI) correlate with markers of renal damage progression in hypertensive patients?
Cross-Sectional (n=121)
No
Does the sonographic atrophic index (AI) correlate with markers of renal damage progression in hypertensive patients?
Absolute Event Rate: 0.71% vs 0.63%
p-value: p=<0.001
The sonographic atrophic index (AI) correlates with markers of renal function decline and may serve as an early marker of renal damage in hypertensive patients.
May support AI as early marker of renal damage in hypertension; leaves open its prognostic value and role in monitoring progression.
Hypertension can cause structural and functional renal damage. Intrarenal ultrasound parameters have been extensively investigated in hypertensive patients and among the parameters introduced, the renal resistive index (RI) is associated with the progression of chronic kidney disease and hypertension. Atrophic index (AI) is an indirect anatomical ultrasound index that reports the atrophic changes of the renal parenchyma and it is mainly studied in chronic glomerular diseases. The present study aimed to evaluate renal RI and AI in hypertensive patients with normal renal function. AI showed correlations with all parameters associated with renal function reduction (age, creatinine, and intrarenal arterial stiffness). AI, in combination with RI, can represent in hypertensive patients an additional marker for renal damage progression.
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Gigante et al. (2022) conducted a cross-sectional in Hypertension (n=121). Hypertension vs. Healthy normotensive controls was evaluated on Atrophic index (AI) (p=<0.001). Hypertension was associated with a significantly higher renal atrophic index compared to healthy controls (0.71 vs 0.63, p < 0.001), which correlated with markers of reduced renal function.
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