Key result
Relief of cardiac tamponade increased plasma atrial natriuretic peptide concentration from 369.5 to 490.3 pg/ml (P<0.05) despite falling right atrial pressure.
Why the study?
Does relief of cardiac tamponade alter plasma atrial natriuretic peptide concentrations?
Observational (n=8)
Does relief of cardiac tamponade alter plasma atrial natriuretic peptide concentrations?
Relief of cardiac tamponade increases atrial natriuretic peptide release, suggesting that atrial stretch rather than atrial pressure is the primary stimulus for its secretion.
Single-case observation warrants no practice change; leaves open atrial stretch as dominant ANP stimulus.
In order to study the role of atrial pressure and atrial stretch on the release of atrial natriuretic peptide we have measured plasma atrial natriuretic peptide concentration, urine output and haemodynamic variables in eight patients during and 30 min after the relief of cardiac tamponade. This condition is characterized by high atrial pressure with little or no atrial stretch. 2. Relief of tamponade was associated with a rise in urine output (53 +/- 27.9 to 101 +/- 24.5 ml/h, mean +/- SEM; P = 0.09), systolic blood pressure (95 +/- 9.6 to 126 +/- 7.0 mmHg, P less than 0.0001), and plasma atrial natriuretic peptide concentration (369.5 +/- 70.9 to 490.3 +/- 94.7 pg/ml, P less than 0.05) despite a large fall in right atrial pressure (18.6 +/- 1.6 to 9.5 +/- 1.3 mmHg, P less than 0.001). 3. These results suggest, therefore, that an increase in atrial stretch, rather than in atrial pressure, stimulates the release of atrial natriuretic peptide.
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J et al. (1990) conducted an observational in Cardiac tamponade (n=8). Relief of cardiac tamponade vs. During cardiac tamponade was evaluated on Plasma atrial natriuretic peptide concentration (pg/ml) (p=<0.05). Relief of cardiac tamponade increased plasma atrial natriuretic peptide concentration from 369.5 to 490.3 pg/ml (P<0.05) despite falling right atrial pressure.
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