February 1, 1991Clinical and Experimental Pharmacology and Physiology

Ionic Mechanisms Regulating Sodium Entry Into Vascular Smooth Muscle

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: ethylisopropylamiloride (EIPA) and diisothio-cyanatostilbenedisulphonic acid (DIDS). Primary outcome: basal sodium influx.

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Key result

Na+/H+ exchange and the EIPA-sensitive Na+ and HCO3- dependent system contribute about 80% to basal sodium influx in cultured human internal mammary artery cells.

Authors

ABAlex BobikBaker Heart and Diabetes Institute PLPeter J. LittleThe University of Queensland CNCraig B. NeylonBabraham Institute

Discussion

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Implication

Does not support clinical translation; leaves open in vivo relevance of these Na+ influx pathways in arteries.

PICO

Exposure / Comparator

ethylisopropylamiloride (EIPA) and diisothio-cyanatostilbenedisulphonic acid (DIDS)

Primary Outcome

basal sodium influx

Cite This Study

Bobik et al. (1991) studied this question. ethylisopropylamiloride (EIPA) and diisothio-cyanatostilbenedisulphonic acid (DIDS) was evaluated on basal sodium influx. Na+/H+ exchange and the EIPA-sensitive Na+ and HCO3- dependent system contribute about 80% to basal sodium influx in cultured human internal mammary artery cells.

synapsesocial.com/papers/6a9aff84f55b623b3bdbe0e0 https://doi.org/10.1111/j.1440-1681.1991.tb01419.x

Topics

Hypertension management

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Ionic Mechanisms Regulating Sodium Entry Into Vascular Smooth Muscle

Discussion

Member takes

Implication

PICO

Cite This Study

Topics

Ionic Mechanisms Regulating Sodium Entry Into Vascular Smooth Muscle

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Topics

Also Consider