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Summary A substance with the characteristics of a specific antibody was found in immune guineapig sera. It had inhibitory activity towards the growth of promastigotes and cytotoxicity to the amastigote form of Leishmania enriettii. The inhibitory effect was shown by direct counting of viable leptomonads. The cytotoxicity of immune sera on amastigotes was evaluated on the basis of morphological changes as well as of a decrease in the number of the organisms. The substance responsible was found to be heat stable and complement dependent. The activity could be removed by the specific absorption.
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Rezai et al. (1972) studied this question.
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