Key result
Changes in ionized plasma calcium during haemodialysis significantly predicted changes in blood pressure (r = 0.69; p < 0.001), counteracting the negative effect of fluid removal.
Why the study?
Does dialysate bicarbonate concentration affect ionized plasma calcium and blood pressure in chronic haemodialysis patients?
Population
7 chronic patients undergoing haemodialysis
Comparison
Dialysis with dialysate containing low… vs Within-subject comparison across the three…
Design
Cohort
Follow-up
3 consecutive weeks
Authors
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Ionized calcium-BP link during haemodialysis should not change practice; leaves open bicarbonate titration effects in randomized trials.
Does dialysate bicarbonate concentration affect ionized plasma calcium and blood pressure in chronic haemodialysis patients?
Effect estimate: r = 0.69
p-value: p=<0.001
Increasing ionized plasma calcium during low-bicarbonate dialysis counteracts the negative effect of fluid removal on blood pressure, highlighting its role in haemodynamic stability.
Leunissen et al. (2008) studied Chronic haemodialysis (n=7). Dialysate bicarbonate concentration was evaluated on Changes in blood pressure (r = 0.69, p=<0.001). Changes in ionized plasma calcium during haemodialysis significantly predicted changes in blood pressure (r = 0.69; p < 0.001), counteracting the negative effect of fluid removal.
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