Key result
Tight glycemic control in patients with severe sepsis or septic shock significantly enhanced fibrinolysis (P<0.001 for PAI-1 activity) and lowered SOFA scores (P=0.03) compared to conventional control.
Why the study?
Does tight glycemic control improve fibrinolysis and reduce morbidity in patients with severe sepsis or septic shock?
Population
90 patients with severe sepsis/septic shock in three Italian university hospital intensive care units.
Comparison
Tight glycemic control vs Conventional glycemic control
Design
RCT, randomized
Follow-up
>28 days (with 90-day mortality assessment)
Authors
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Supports tighter glycemic targets in severe sepsis or septic shock; extends RCT evidence to fibrinolysis and organ dysfunction endpoints.
RCT (n=90)
randomized
Yes
Does tight glycemic control improve fibrinolysis and reduce morbidity in patients with severe sepsis or septic shock?
p-value: p=<0.001
In patients with severe sepsis or septic shock, tight glycemic control may improve fibrinolysis and reduce morbidity compared to conventional glycemic targets.
Savioli et al. (2009) conducted an RCT in severe sepsis/septic shock (n=90). Tight glycemic control vs. conventional glycemic control (target glycemia, 180-200 mg/dL) was evaluated on Fibrinolysis markers (PAI-1 activity) and Sepsis-related Organ Failure Assessment (SOFA) score (p=<0.001). Tight glycemic control in patients with severe sepsis or septic shock significantly enhanced fibrinolysis (P<0.001 for PAI-1 activity) and lowered SOFA scores (P=0.03) compared to conventional control.
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