What is the clinical evidence from this study?

Study design: Other. Population: African swine fever. Intervention: ASFV-G-Δ9GL/ΔUK. Primary outcome: Protection against challenge with ASFV-G.

October 27, 2016Journal of VirologyOpen Access

Simultaneous Deletion of the9GLandUKGenes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge

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Key result

The double-gene-deletion recombinant virus ASFV-G-Δ9GL/ΔUK safely protected swine against the highly virulent ASFV Georgia 2007 isolate as early as 14 days postvaccination.

Authors

VOVivian O’DonnellAnimal and Plant Health Inspection Service GRGuillermo R. RisattiUniversity of Connecticut LHLauren G. HolinkaUnited States Department of Agriculture

Discussion

Member takes

Implication

Supports early ASFV protection in swine; leaves open field efficacy and commercial translation.

PICO

Population

Swine evaluated for protection against African swine fever virus using a double-gene-deletion recombinant virus vaccine.

Intervention / Comparator

ASFV-G-Δ9GL/ΔUK (10^4 to 10^6 HAD50)

Primary Outcome

Protection against challenge with ASFV-G

Cite This Study

O’Donnell et al. (2016) studied African swine fever. ASFV-G-Δ9GL/ΔUK was evaluated on Protection against challenge with ASFV-G. The double-gene-deletion recombinant virus ASFV-G-Δ9GL/ΔUK safely protected swine against the highly virulent ASFV Georgia 2007 isolate as early as 14 days postvaccination.

synapsesocial.com/papers/6a9b09fbebbd1a612aaca9a7 https://doi.org/10.1128/jvi.01760-16

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Simultaneous Deletion of the9GLandUKGenes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge

Discussion

Member takes

Implication

PICO

Cite This Study

Simultaneous Deletion of the9GLandUKGenes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider