Fas andFasLExpression in Human Adipose Tissue Is Related to Obesity, Insulin Resistance, and Type 2 Diabetes
Key result
Fas expression in omental adipose tissue significantly correlated with BMI (r2=0.44), macrophage infiltration (r2=0.36), and glucose infusion rate (r2=0.17) (P<.05 for all).
Population
256 lean and obese participants, and an additional 16 obese patients undergoing a two-step bariatric surgery…
Design
Cross-sectional
Follow-up
12 months (for the bariatric surgery subgroup)
Authors
Discussion
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Implication
Fas links adipose inflammation to insulin resistance in obesity; leaves open causal role and therapeutic targeting.
Study Design
Type
Observational (n=272)
Structured PICO
P
Population
256 lean and obese participants, along with 16 obese patients evaluated 12 months after significant weight loss following bariatric surgery.
O
Outcome
Fas and Fas-ligand (FasL) mRNA expression in omental and subcutaneous adipose tissue, and their correlation with BMI, adipose tissue inflammation, and insulin sensitivity.surrogate
Main Result
Effect estimate: r2=0.44
p-value: p=<.05
Increased Fas expression in adipose tissue is associated with impaired insulin sensitivity and adipose tissue dysfunction in obesity, and is significantly reduced following weight loss.
Cite This Study
Blüher et al. (2013) conducted an observational in Obesity and Insulin Resistance (n=272). Obesity and insulin resistance vs. Lean and insulin-sensitive individuals was evaluated on Correlation of Fas expression with body mass index in omental adipose tissue (r2=0.44, p=<.05). Fas expression in omental adipose tissue significantly correlated with BMI (r2=0.44), macrophage infiltration (r2=0.36), and glucose infusion rate (r2=0.17) (P<.05 for all).