Key result
Severe insulin-resistant diabetes is linked to higher intrahepatic lipids and visceral fat versus other endotypes.
Why the study?
Are skeletal muscle or adipose tissue lipids elevated in the severe insulin-resistant diabetes (SIRD) endotype compared to other endotypes, and do they correlate with cardiovascular risk?
Observational (n=420)
Are skeletal muscle or adipose tissue lipids elevated in the severe insulin-resistant diabetes (SIRD) endotype compared to other endotypes, and do they correlate with cardiovascular risk?
p-value: p=<0.01
The severe insulin-resistant diabetes endotype is associated with higher intrahepatic lipids and visceral adipose tissue, which correlate with increased cardiovascular risk.
OBJECTIVE: The severe insulin-resistant diabetes (SIRD) endotype is associated with metabolic dysfunction-associated steatotic liver disease and higher cardiovascular risk. We investigated whether skeletal muscle or adipose tissue lipids are elevated in SIRD. RESEARCH DESIGN AND METHODS: Participants (N = 420) of the German Diabetes Study (GDS) were assigned to diabetes clusters using a validated algorithm. 1H-magnetic resonance methods were used to quantify intramyocellular lipids (IMCLs), intrahepatic lipids (IHLs), and visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) volumes. RESULTS: Aside from elevated IHLs (P < 0.01), SIRD showed higher VAT and SAT than other endotypes after adjustment for BMI (all P < 0.05) but not for multiple comparisons. All endotypes featured comparable IMCLs. VAT volume and IHLs correlated with cardiovascular risk scores (Framingham r = 0.661 and 0.548, respectively, P < 0.05). Polygenic risk scores for VAT were associated with higher cardiovascular risk. CONCLUSIONS: SIRD features higher IHLs and nominally higher VAT volume, which likely contribute to increased cardiovascular risk, highlighting implications for tailored prevention and treatment.
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Zaharia et al. (2025) conducted an observational in Diabetes (n=420). Severe insulin-resistant diabetes (SIRD) endotype vs. Other diabetes endotypes was evaluated on Intrahepatic lipids (IHLs), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) volumes (p=<0.01). The severe insulin-resistant diabetes endotype was associated with higher intrahepatic lipids (P<0.01) and visceral adipose tissue compared to other diabetes endotypes.
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