Key result
Atenolol decreased portal venous pressure significantly less than propranolol in patients with cirrhosis, despite similar reductions in cardiac output.
Why the study?
Does atenolol compared to propranolol reduce portal venous pressure in patients with portal hypertension due to cirrhosis?
Population
Patients with portal hypertension due to cirrhosis
Comparison
Atenolol 100 mg oral single dose vs Propranolol 40 mg oral single dose
Design
Other
Follow-up
1 hour
Authors
Loading...
May support propranolol over atenolol for portal pressure in cirrhosis; leaves open need for confirmatory trials on selective agents.
Does atenolol compared to propranolol reduce portal venous pressure in patients with portal hypertension due to cirrhosis?
Propranolol is more effective than atenolol in reducing portal venous pressure in cirrhotic patients due to its additional extracardiac effects.
Hillon et al. (1982) studied Portal hypertension due to cirrhosis. Atenolol vs. Propranolol was evaluated on Cardiac output and portal venous pressure. Atenolol decreased portal venous pressure significantly less than propranolol in patients with cirrhosis, despite similar reductions in cardiac output.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: