Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation

Yunpeng Zhao; Cheng Qiu; Wenhan Wang; Jiangfan Peng; Xiang Cheng; Yangtao Shangguan; Mingyang Xu; Jiayi Li; Ruize Qu; Suyi Jia; Dan Luo; Long Liu; Peng Li; Fengjin Guo; Krasimir Vasilev; Liang Liu; John D. Hayball; Shuli Dong; Xin Pan; Yuhua Li; Linlin Guo; Lei Cheng; Weiwei Li

doi:10.7150/thno.45359

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Abstract

This study suggests the role of CST in mitochondrial ROS and activation of the NLRP3 inflammasome in IVD degeneration, which might shed light on therapeutic targets for IVD degeneration.

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Zhao et al. (2020) studied this question.

synapsesocial.com/papers/6a9b115ab468c03968ec7319 https://doi.org/10.7150/thno.45359

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Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation

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Abstract

Discussion

Cite This Study

Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation

Ask about this paper

Abstract

Discussion

Cite This Study

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