Key result
Diets containing beef tallow and lard of coconut oil induced thrombosis and thromboembolic disease in dogs with atherosclerosis, whereas these complications were absent with cottonseed oil diets.
The source of dietary fat alters the occurrence of thrombosis in canine models of atherosclerosis, providing a useful model for studying thrombostatic mechanisms.
Dietary fat source may affect thrombosis in atherosclerotic dogs; leaves open human translation and requires prospective study.
The distribution, severity, and complications of diet-induced atherosclerosis in dogs can be altered by changing the source of fat in the diet. Thrombosis and thromboembolic disease associated with atherosclerosis occurred with diets containing beef tallow and lard of coconut oil but were absent in dogs fed cottonseed oil as a source of fat. Experiemtnal animals with and without thrombosis are of value as models in elucidating the role of platelets and thrombostatic mechanisms in atherosclerosis.
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Mahley et al. (1976) studied Diet-induced atherosclerosis. Diets containing beef tallow and lard of coconut oil vs. Diets containing cottonseed oil was evaluated on Thrombosis and thromboembolic disease. Diets containing beef tallow and lard of coconut oil induced thrombosis and thromboembolic disease in dogs with atherosclerosis, whereas these complications were absent with cottonseed oil diets.
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