Key result
An atherogenic regimen induces MI in ~90% of aged male dogs.
Why the study?
Does an atherogenic regimen induce myocardial infarction in aged male mongrel dogs?
Does an atherogenic regimen induce myocardial infarction in aged male mongrel dogs?
An atherogenic regimen leading to severe hypercholesterolemia induces myocardial infarction in aged dogs, suggesting that advanced age plays a role in the genesis of infarction.
Severe hypercholesterolemia may induce MI in aged canines; hypothesis-generating for age effects but should not change human practice.
Male, mongrel dogs, six to eight years of age, were placed on an atherogenic regimen which included I 131 administration and/or thiouracil with cholesterol feeding and, in some cases, the addition of 10 per cent lard to the diet. As is usually observed in such experiments, the degree of hypercholesterolemia and atheromatosis varied greatly. However, in nine out of ten dogs with blood cholesterol levels of 1,800 mg. per cent or above for over 16 weeks, myocardial infarction appeared (a) spontaneously, (b) after pitressin administration, and (c) after exposure to a stresser. Myocardial infarction has been noticed only rarely previously. Reasons are given for the belief that the advanced age of the animals which were used here played a role in the genesis of infarction.
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Sobel et al. (1962) studied Atherosclerosis. Atherogenic regimen (I 131, thiouracil, cholesterol feeding, lard) was evaluated on Myocardial infarction. An atherogenic regimen resulting in blood cholesterol levels ≥1,800 mg% for over 16 weeks induced myocardial infarction in 9 out of 10 aged male dogs.
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