Does induced hypertension increase the severity of aortic atherosclerosis in dogs with hypercholesterolemia?
In a canine model, both induced hypertension and marked hypercholesterolemia independently increase the severity of aortic atherosclerosis.
Hypercholesterolemia was induced in pure-bred dogs by cholesterol feeding and propylthiouracil or radioiodine. Hypertension induced by the injection of silica into the renal artery increased the severity of aortic atherosclerosis. Marked hypercholesterolemia increased the severity of aortic atherosclerosis even in normotensive dogs.
Campbell Moses (Sat,) studied this question.