Why the study?
Does induced hypertension increase the severity of aortic atherosclerosis in dogs with hypercholesterolemia?
Does induced hypertension increase the severity of aortic atherosclerosis in dogs with hypercholesterolemia?
In a canine model, both induced hypertension and marked hypercholesterolemia independently increase the severity of aortic atherosclerosis.
Both hypertension and hypercholesterolemia may worsen aortic atherosclerosis; leaves open translation from canine models to human disease.
Hypercholesterolemia was induced in pure-bred dogs by cholesterol feeding and propylthiouracil or radioiodine. Hypertension induced by the injection of silica into the renal artery increased the severity of aortic atherosclerosis. Marked hypercholesterolemia increased the severity of aortic atherosclerosis even in normotensive dogs.
No takes yet. Share an insight, caveat, or question.
Campbell Moses (1954) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: