Why the study?
Does experimental renal hypertension accelerate atherosclerosis in dogs with thiouracil-cholesterol atherosclerosis?
Does experimental renal hypertension accelerate atherosclerosis in dogs with thiouracil-cholesterol atherosclerosis?
Experimental renal hypertension accelerates atherosclerosis in a dog model independent of changes in serum lipids.
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Renal hypertension may accelerate atherosclerosis independently of lipids in dogs; leaves open relevance to human disease.
Experimental renal hypertension accelerated the onset and accentuated the severity of thiouracil-cholesterol atherosclerosis in dogs. Increased blood pressure and other hemodynamic changes appear to be responsible for these effects. Hypertension and sex were without significant effect on serum cholesterol, cholesterol: phospholipid ratio and low density lipoproteins. Sex had no significant effect on the incidence or severity of this experimental atherosclerosis, including coronary involvement.
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Wakerlin et al. (1957) studied this question.
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