Why the study?
Does hypertension (high or normal renin) increase atherosclerosis in hyperlipidemic baboons?
Population
48 moderately hyperlipidemic baboons (Papio sp.)
Comparison
Induction of hypertension via renal artery… vs Control group (normotensive)
Design
Preclinical
Authors
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Supports hypertension-atherosclerosis link in hyperlipidemic baboons; leaves open human translation and clinical relevance.
Does hypertension (high or normal renin) increase atherosclerosis in hyperlipidemic baboons?
Hypertension, regardless of plasma renin activity, significantly increases the extent of atherosclerosis in hyperlipidemic baboons, particularly in the carotid arteries.
McGill et al. (1985) studied this question.
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