Key result
Hypercholesterolemia worsens hypertension-induced renal injury, oxidative stress, and inflammation in a rat model.
Why the study?
The study investigated the effect of hypercholesterolemia on hypertension-induced renal injury and its underlying mechanisms.
Does hypercholesterolemia enhance hypertension-induced renal injury in rats?
Does hypercholesterolemia enhance hypertension-induced renal injury in rats?
In a rat model, hypercholesterolemia exacerbates hypertension-induced renal injury, likely through increased oxidative stress and inflammation.
Answers are grounded in this paper and cite their sources.
May worsen hypertensive kidney injury in rats; hypothesis-generating and leaves open human relevance pending clinical studies.
The effect of hypercholesterolemia on hypertension-induced renal injury was investigated in rats. Hypertension was induced by L-N(G)-nitroarginine methyl ester (L-NAME) and Hypercholesterolemia was induced by feeding rats with a diet containing 1% cholesterol. In these animals L-NAME produced a progressive increase in the systolic, diastolic and mean arterial Blood Pressure (BP). Similarly, L-NAME with hypercholesterolemia produced, in addition to compromised serum lipid profile, a progressive increase in the systolic, diastolic and mean arterial BP. Hypercholesterolemia enhanced the hypertensive effect of L-NAME. Also, hypercholesterolemia enhanced hypertension-induced renal injury as assessed by measurement of serum renal function markers and by histopathological examination. Concomitantly, hypertension-induced elevation of renal tissue Malondialdehyde (MDA) and nitrite levels and reduction of intracellular reduced Glutathione (GSH) level were enhanced by hypercholesterolemia. In addition, hypertension -induced increases in tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β) and Intercellular Adhesion Molecule-1 (ICAM-1) levels in renal tissues were increased by hypercholesterolemia. These results indicate that hypercholesterolemia has the ability to enhance hypertension-induced renal injury. The ability of hypercholesterolemia to provide this effect may positively correlate to its ability to increase renal oxidative stress, nitrosative stress and inflammation.
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O et al. (2020) studied Hypertension-induced renal injury. Hypercholesterolemia vs. Hypertension without hypercholesterolemia (L-NAME alone) was evaluated on Renal injury (assessed by serum renal function markers, histopathology, oxidative stress, and inflammation). In a rat model, hypercholesterolemia enhanced hypertension-induced renal injury, oxidative stress, nitrosative stress, and inflammation compared to hypertension alone.
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