Combination of Hypercholesterolemia and Hypertension Augments Renal Function Abnormalities
Why the study?
Does the combination of hypercholesterolemia and hypertension augment impairment in renal function and redox status compared to either condition alone in a porcine model?
Population
Pigs (n=33 total)
Comparison
Combined hypercholesterolemic diet and… vs Normal diet, hypercholesterolemic diet alone, or…
Design
Preclinical
Follow-up
12 weeks
Authors
Discussion
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Member takes
Implication
Combined hypercholesterolemia and hypertension may synergistically impair renal perfusion in porcine models; leaves open translation to human cardiorenal outcomes.
Structured PICO
Does the combination of hypercholesterolemia and hypertension augment impairment in renal function and redox status compared to either condition alone in a porcine model?
P
Population
Pigs (n=33 total)
I
Intervention
Combined hypercholesterolemic diet and renovascular hypertension for 12 weeks
C
Comparator
Normal diet (n=10), hypercholesterolemic diet alone (n=10), or renovascular hypertension alone (n=7)
O
Outcome
Regional renal hemodynamics and function in response to vasoactive challenges with acetylcholine or sodium nitroprusside quantified by electron-beam computed tomographysurrogate
Concurrent hypercholesterolemia and hypertension have a synergistic detrimental effect on renal perfusion responses and redox status in a porcine model, potentially accelerating renal injury.
Cite This Study
Rodriguez‐Porcel et al. (2001) studied this question.