Hypercholesterolemia and Hypertension Have Synergistic Deleterious Effects on Coronary Endothelial Function

32 pigs divided into four groups: normal diet (n=9), 2% hypercholesterolemia diet (n=9), hypertension via unilateral renal artery stenosis (n=8), or both (n=6).

Coexisting hypercholesterolemia (2% HC diet) and hypertension (unilateral renal artery stenosis) for 12 weeks

Normal diet, hypercholesterolemia alone, or hypertension alone

Coronary endothelial function (vasodilatory response to bradykinin and calcium ionophore) and oxidative stress in coronary artery tissuesurrogate