Key result
Both renovascular hypertension and a high cholesterol diet induced endothelial dysfunction in pig carotid arteries, but hypertension caused greater fibrosis and wall thickening.
Authors
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Animal data indicate hypertension drives greater carotid fibrosis than hypercholesterolemia; leaves open differential mechanisms in human atherosclerosis.
RCT (n=17)
Randomized
Versari et al. (2007) conducted an RCT in Hypertension and Hypercholesterolemia (n=17). Renovascular hypertension or high cholesterol diet vs. Normal diet was evaluated on Carotid endothelial function, structure, and vasa vasorum density. Both renovascular hypertension and a high cholesterol diet induced endothelial dysfunction in pig carotid arteries, but hypertension caused greater fibrosis and wall thickening.
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