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February 1, 2002HypertensionOpen Access

Coexistence of Hypercholesterolemia and Hypertension Impairs Adventitial Vascularization

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Key result

Coexistence of hypercholesterolemia and hypertension impaired adventitial vasa vasorum formation and caused persistent medial hypoxia in rats compared to hypertension alone.

Population

Wistar rats (n=20, 5 per group)

Comparison

Coexistence of hypercholesterolemia and… vs Control, hypercholesterolemia alone, and…

Design

Preclinical

Follow-up

28 days

Authors

HKHisashi KaiKurume UniversityFKFumitaka KuwaharaKurume UniversityKTKeisuke TokudaRitsumeikan University

Discussion

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Implication

Hypothesis-generating for vasa vasorum impairment in comorbid hypertension and hypercholesterolemia; leaves open relevance to human arteriosclerosis.

Structured PICO

P
Population
20 Wistar rats assigned to control, hypercholesterolemia, hypertension, or combined groups to assess vascular changes over 28 days.
I
Intervention
Coexistence of hypercholesterolemia (high-cholesterol diet from Day -14) and hypertension (suprarenal aortic constriction at Day 0)
C
Comparator
Control (standard diet + sham operation), hypercholesterolemia alone (HC), and hypertension alone (HT)
O
Outcome
Adventitial vasa vasorum (AVV) density, adventitial area, and medial thickness in the ascending aorta at Day 28surrogate

The coexistence of hypercholesterolemia and hypertension impairs adventitial vascularization, resulting in persistent medial hypoxia that may drive arteriosclerosis.

Cite This Study

Kai et al. (2002) studied Hypercholesterolemia and hypertension (n=20). Combined hypercholesterolemia and hypertension vs. Control, hypercholesterolemia alone, or hypertension alone was evaluated on Adventitial vasa vasorum density, adventitial area, and medial thickness. Coexistence of hypercholesterolemia and hypertension impaired adventitial vasa vasorum formation and caused persistent medial hypoxia in rats compared to hypertension alone.

synapsesocial.com/papers/6a9fe883db4aac333b44ab4ahttps://doi.org/10.1161/hy0202.103001

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor Pathway for Adventitial Vasa Vasorum Formation in Hypertensive Rat Aorta2002 · 106 citations
  2. 2Role of Rho-Associated Kinase in Neointima Formation After Vascular Injury2001 · 126 citations
  3. 3Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells.1990 · 390 citations
  4. 4Nature of Species Differences in the Medial Distribution of Aortic Vasa Vasorum in Mammals1967 · 337 citations
  5. 5Diffusional support of arteries1985 · 38 citations