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January 27, 2005Arteriosclerosis Thrombosis and Vascular Biology

Coronary vasa vasorum density was higher in HC than N and HT (3.4+/-1.0 vs 1.9+/-0.3 and 2.0+/-1.2; P<0.05), while HT showed higher collagen III content and adventitial myofibroblasts compared with N and HC.

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Population

16 female domestic pigs

Comparison

High-cholesterol diet or renovascular… vs Normal diet (N) for 12 weeks

Design

Preclinical, randomized to one of the following 12-week treatment groups

Follow-up

12 weeks

Authors

JHJoerg HerrmannSSSaquib SameeACAlejandro Chade

Discussion

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Overview

Hypothesis-generating for risk factor-specific adventitial remodeling in animals; leaves open relevance to human atherosclerosis progression.

Structured PICO

P
Population
16 female domestic pigs
I
Intervention
High-cholesterol diet (HC) or renovascular hypertension (HT) for 12 weeks
C
Comparator
Normal diet (N) for 12 weeks
O
Outcome
Adventitial remodeling (coronary vasa vasorum density, collagen III content, presence of adventitial myofibroblasts) and intima-media remodeling (external elastic lamina-to-lumen area [EELLA] ratio)surrogate

Adventitial remodeling precedes intima-media remodeling early after exposure to hypercholesterolemia and hypertension, with distinct qualitative differences depending on the risk factor.

Cite This Study

Herrmann et al. (2005) studied this question.

synapsesocial.com/papers/6a21697e5c0c8498e257ffc9https://doi.org/10.1161/01.atv.0000152606.34120.97
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