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August 1, 2002Cardiovascular Research

Twenty-eight days after angioplasty, lumen increase was significantly lower in hypercholesterolemic pigs compared to controls (0.08+/-1.7 mm² vs 2.7+/-2.7 mm², P=0.016).

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Why the study?

Does hypercholesterolemia impair vascular remodeling after coronary angioplasty in a porcine model?

Population

21 miniature pigs (16 age-matched hypercholesterolemic and 5 control)

Comparison

Left anterior descending coronary angioplasty in… vs Left anterior descending coronary angioplasty in…

Design

Preclinical

Follow-up

28 days

Authors

GTGregor Theilmeier

Discussion

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Overview

Hypercholesterolemia may impair post-angioplasty remodeling in pigs; leaves open human relevance and requires clinical validation.

Structured PICO

Does hypercholesterolemia impair vascular remodeling after coronary angioplasty in a porcine model?

P
Population
21 miniature pigs (16 age-matched hypercholesterolemic and 5 control)
I
Intervention
Left anterior descending coronary angioplasty in the setting of hypercholesterolemia
C
Comparator
Left anterior descending coronary angioplasty in control pigs
O
Outcome
Vascular remodeling (lumen increase) and neointima formation at 28 dayssurrogate

Hypercholesterolemia impairs vascular remodeling and decreases smooth muscle cell and collagen accumulation after coronary angioplasty in a porcine model.

Cite This Study

Gregor Theilmeier (2002) studied this question.

synapsesocial.com/papers/6a2275a7faaf5defc96cd5f5https://doi.org/10.1016/s0008-6363(02)00409-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Differential Effect of Experimental Hypertension and Hypercholesterolemia on Adventitial Remodeling2005 · 63 citations
  2. 2Hypercholesterolemia enhances macrophage recruitment and dysfunction of regenerated endothelium after balloon injury of the rabbit iliac artery.1991 · 73 citations
  3. 3Enhanced Endothelin-Mediated Coronary Vasoconstriction and Attenuated Basal Nitric Oxide Activity in Experimental Hypercholesterolemia1997 · 102 citations
  4. 4Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigs2002 · 67 citations
  5. 5Impaired endothelium-dependent relaxation to aggregating platelets and related vasoactive substances in porcine coronary arteries in hypercholesterolemia and atherosclerosis.1989 · 354 citations