Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1999HypertensionOpen Access

In Vivo Renal Vascular and Tubular Function in Experimental Hypercholesterolemia

View Full Paper
Ask AI
Bookmark
Share

Population

22 domestic pigs fed a 12-week normal (n=11) or hypercholesterolemic (HC) (n=11) diet

Comparison

Suprarenal infusion of either acetylcholine or… vs Normal diet pigs receiving the same infusions

Design

Preclinical

Follow-up

12 weeks

Authors

AFAriel E. FeldsteinPfizer (United States)JKJames D. KrierMayo ClinicMSMirit Hershman SarafovMayo Clinic

Discussion

Loading...

Member takes

Implication

Attenuated renal vasodilator responses in hypercholesterolemic pigs should not change practice; leaves open NO bioavailability mechanisms in human hypertension.

Structured PICO

P
Population
22 domestic pigs fed a 12-week normal (n=11) or hypercholesterolemic (HC) (n=11) diet
I
Intervention
Suprarenal infusion of either acetylcholine (6 pigs of each diet) or sodium nitroprusside (SNP; 5 pigs of each diet)
C
Comparator
Normal diet pigs receiving the same infusions
O
Outcome
Renal regional perfusion and intratubular contrast media concentration in each nephron segment (representing fluid reabsorption) quantified in vivo with electron-beam computed tomographysurrogate

Early experimental hypercholesterolemia in pigs attenuates renal perfusion response to both endothelium-dependent and -independent vasodilators, suggesting decreased nitric oxide bioavailability or responsiveness.

Cite This Study

Feldstein et al. (1999) studied this question.

synapsesocial.com/papers/6a88eb798642fe04be696bdfhttps://doi.org/10.1161/01.hyp.34.4.859
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys.1984 · 368 citations
  2. 2Endothelium-dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates.1990 · 231 citations
  3. 3Inhibition of proximal tubular fluid absorption by nitric oxide and atrial natriuretic peptide in rat kidney1998 · 93 citations
  4. 4Differences in Onset of Impaired Endothelial Responses and in Effects of Vitamin E in the Hypercholesterolemic Rabbit Carotid and Renal Arteries1995 · 30 citations