Why the study?
Does irbesartan improve renal perfusion and functional responses in a hypercholesterolemic pig model?
Population
18 pigs assigned to normal diet, hypercholesterolemic diet, or hypercholesterolemic diet with AT1-receptor…
Comparison
Irbesartan 100 mg/d supplemented to a… vs Normal diet alone and hypercholesterolemic diet…
Design
Preclinical
Follow-up
12 weeks
Authors
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May inform renal protection strategies in hypercholesterolemia; leaves open translation from porcine models to patients.
Does irbesartan improve renal perfusion and functional responses in a hypercholesterolemic pig model?
AT1 receptor blockade with irbesartan preserves renal cortical perfusion and tubular function in a porcine model of hypercholesterolemia, likely by reducing oxidative stress.
Alejandro Chade (2003) studied this question.
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