October 1, 1999Hypertension

AT ₁ Receptor Antagonism Reduces Endothelial Dysfunction and Intimal Thickening in Atherosclerotic Rabbits

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Why the study?

Does valsartan reduce endothelial dysfunction and intimal thickening in atherosclerotic rabbits?

Structured PICO

Does valsartan reduce endothelial dysfunction and intimal thickening in atherosclerotic rabbits?

Population

Rabbits fed with either a control diet or a cholesterol-enriched diet

Intervention

Valsartan 3 or 10 mg/kg per day for 10 weeks

Comparator

No valsartan (control diet or cholesterol-enriched diet alone)

Outcome

Endothelial function (acetylcholine-induced relaxation) and structural changes in aorta (intimal lesion, lumen and media cross-sectional areas)surrogate

Valsartan reduces endothelial dysfunction and intimal thickening in a rabbit model of atherosclerosis, independent of blood pressure or cholesterol levels.

Discussion

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Implication

Hypothesis-generating in rabbit atherosclerosis models; leaves open translation to human plaque progression.

Cite This Study

Aragoncillo et al. (1999) studied this question.

synapsesocial.com/papers/6a854b34734852141cd4c43e https://doi.org/10.1161/01.hyp.34.4.969

View Full Paper

Ask AI

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AT ₁ Receptor Antagonism Reduces Endothelial Dysfunction and Intimal Thickening in Atherosclerotic Rabbits

Structured PICO

Discussion

Implication

Cite This Study

AT ₁ Receptor Antagonism Reduces Endothelial Dysfunction and Intimal Thickening in Atherosclerotic Rabbits

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider