Why the study?
Does irbesartan reduce aortic atherosclerosis in Watanabe heritable hyperlipidemic rabbits?
Population
Watanabe heritable hyperlipidemic rabbits
Comparison
Irbesartan at 30 mg/kg/day or 75 mg/kg/day vs Controls
Design
Preclinical
Authors
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Irbesartan attenuates aortic atherosclerosis in hyperlipidemic rabbits; leaves open translation to human cardiovascular outcomes.
Does irbesartan reduce aortic atherosclerosis in Watanabe heritable hyperlipidemic rabbits?
High-dose AT1 receptor blockade with irbesartan reduces aortic atherosclerosis in hypercholesterolemic rabbits, comparable to previous findings with ACE inhibitors.
Sandra Hope (1999) studied this question.
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