Why the study?
Do ACE inhibitors (captopril, quinapril) or ARBs (losartan) prevent atherosclerosis and preserve vascular function in a rabbit model on a high-cholesterol diet?
Population
n=42 New Zealand rabbits on a 0.5% cholesterol diet
Comparison
Captopril, quinapril, or losartan for 14 weeks vs Control group receiving 0.5% cholesterol diet…
Design
Preclinical, randomized
Follow-up
14 weeks
Authors
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Preclinical superiority of ACEIs over ARBs for endothelial preservation warrants clinical caution; leaves open translation to human atherosclerosis.
Do ACE inhibitors (captopril, quinapril) or ARBs (losartan) prevent atherosclerosis and preserve vascular function in a rabbit model on a high-cholesterol diet?
In a hypercholesterolemic rabbit model, ACE inhibitors and ARBs similarly reduced atherogenesis, but ACE inhibitors were superior in preserving vascular endothelial function.
Sun et al. (2001) studied this question.
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