Key result
Oral administration of the ACE inhibitor captopril for 9 months significantly reduced the development of atherosclerosis in the descending thoracic aorta of normotensive WHHL rabbits.
Why the study?
Does captopril administered orally for 9 months reduce the development of atherosclerosis in normotensive Watanabe heritable hyperlipidemic (WHHL) rabbits?
Population
normotensive Watanabe heritable hyperlipidemic (WHHL) rabbits
Comparison
captopril administered orally for 9 months vs controls
Design
Preclinical
Follow-up
9 months
Authors
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Captopril attenuated atherosclerosis in resistant WHHL rabbits; hypothesis-generating and leaves open translation to human disease.
Does captopril administered orally for 9 months reduce the development of atherosclerosis in normotensive Watanabe heritable hyperlipidemic (WHHL) rabbits?
Captopril inhibits atherogenesis in the WHHL rabbit model, which has typically been resistant to antiatherosclerotic effects of other antihypertensive drugs.
Aram V. Chobanian (2009) studied Atherosclerosis. Captopril vs. Controls was evaluated on Development of atherosclerosis in the descending thoracic aorta. Oral administration of the ACE inhibitor captopril for 9 months significantly reduced the development of atherosclerosis in the descending thoracic aorta of normotensive WHHL rabbits.
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