Why the study?
Does low-dose trandolapril reduce atherosclerosis in Watanabe heritable hyperlipidemic rabbits?
Does low-dose trandolapril reduce atherosclerosis in Watanabe heritable hyperlipidemic rabbits?
The antiatherosclerotic effect of ACE inhibitors may not be directly related to arterial enzyme inhibition, as low-dose trandolapril suppressed ACE activity without reducing atherosclerosis in WHHL rabbits.
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Questions direct link between ACE inhibition and atherosclerosis reduction in hyperlipidemic models; leaves open alternative mechanisms or dosing effects.
Chobanian et al. (1995) studied this question.
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