Why the study?
Does trandolapril, verapamil, or their combination prevent arterial pressure increase and aortic structural changes in rats with induced hypertension?
Population
Wistar rats rendered hypertensive by extensive renal mass ablation
Comparison
Trandolapril, verapamil, or their combination… vs Placebo
Design
Preclinical
Follow-up
6 months
Authors
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Supports trandolapril for aortic protection in rat hypertension; hypothesis-generating and leaves open human translation.
Does trandolapril, verapamil, or their combination prevent arterial pressure increase and aortic structural changes in rats with induced hypertension?
In a rat model of induced hypertension, trandolapril alone or in combination with verapamil effectively controlled blood pressure and prevented aortic structural alterations, whereas verapamil alone was ineffective.
López‐Hernández et al. (1999) studied this question.
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