Why the study?
Does trandolapril, verapamil, or their combination reduce arterial pressure and improve aortic structure and function in spontaneously hypertensive rats after unilateral nephrectomy?
Does trandolapril, verapamil, or their combination reduce arterial pressure and improve aortic structure and function in spontaneously hypertensive rats after unilateral nephrectomy?
In a hypertensive rat model with reduced renal mass, trandolapril alone or combined with verapamil effectively normalizes blood pressure and improves endothelial dysfunction.
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Hypothesis-generating in this rat model; leaves open translation to human hypertension with reduced renal mass.
López‐Hernández et al. (1998) studied this question.
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