Why the study?
Does the combination of trandolapril and verapamil SR reduce blood pressure more effectively than either agent alone or placebo in patients with mild-to-moderate essential hypertension?
Population
631 outpatients with mild-to-moderate (stages I and II) essential hypertension
Comparison
Combination of 4 mg trandolapril and 240 mg… vs Placebo, 4 mg trandolapril alone, or 240 mg…
Design
RCT, randomized, parallel, double-blind
Follow-up
10 weeks
Authors
Loading...
Supports combination over monotherapy for greater BP reduction in mild-to-moderate hypertension; confirms additive efficacy in this RCT.
Does the combination of trandolapril and verapamil SR reduce blood pressure more effectively than either agent alone or placebo in patients with mild-to-moderate essential hypertension?
The combination of trandolapril and verapamil SR is well tolerated and more effective than either agent alone for the treatment of mild-to-moderate essential hypertension.
Franz H. Messerli (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: