Key result
Trandolapril-verapamil combination therapy decreased mean and pulse pressures to a greater extent than either monotherapy, with arterial changes influenced primarily by the measurement site.
Why the study?
Does trandolapril-verapamil combination therapy improve arterial structure and hemodynamics compared to monotherapy in hypertensive patients?
Population
Hypertensive patients
Comparison
Trandolapril-verapamil combination therapy for… vs Verapamil monotherapy or trandolapril monotherapy
Design
RCT, double-blind
Follow-up
180 days
Authors
Loading...
Supports combination therapy for superior pressure reduction in hypertension; extends site-specific arterial response data.
RCT
Double-blind
Does trandolapril-verapamil combination therapy improve arterial structure and hemodynamics compared to monotherapy in hypertensive patients?
Trandolapril-verapamil combination therapy provides greater reductions in mean and pulse pressures than either monotherapy, while similarly improving arterial distensibility and reducing cardiac hypertrophy.
Topouchian et al. (1999) conducted an RCT in Hypertension. Trandolapril-verapamil combination vs. Verapamil alone or trandolapril alone was evaluated on Mean pressure, local pulse pressure, arterial diameter, and distensibility at 3 arterial sites, and cardiac and carotid wall structure. Trandolapril-verapamil combination therapy decreased mean and pulse pressures to a greater extent than either monotherapy, with arterial changes influenced primarily by the measurement site.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: