Key result
Trandolapril and HR 720 significantly decreased the area of atherosclerotic lesions in the thoracic aorta of monkeys fed a high-cholesterol diet.
Why the study?
Does trandolapril or HR 720 prevent the development of atherosclerotic lesions in Cynomolgus monkeys fed a high-cholesterol diet?
Population
Cynomolgus monkeys (Macaca fascicularis) fed a high-cholesterol (4% cholesterol and 6% corn oil) diet
Comparison
Trandolapril or HR 720 for 6 months vs Normal diet group and untreated cholesterol-diet…
Design
Preclinical
Follow-up
6 months
Authors
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Supports angiotensin blockade for atherosclerosis in primates; leaves open human translation pending clinical trials.
Does trandolapril or HR 720 prevent the development of atherosclerotic lesions in Cynomolgus monkeys fed a high-cholesterol diet?
Blockade of angiotensin II function by ACE inhibition or AT1 receptor antagonism prevents the development of atherosclerotic lesions in a non-human primate model of hypercholesterolemia.
Miyazaki et al. (1999) studied Atherosclerosis. Trandolapril and HR 720 vs. Cholesterol-diet control was evaluated on Area of atherosclerotic lesions in the thoracic aorta. Trandolapril and HR 720 significantly decreased the area of atherosclerotic lesions in the thoracic aorta of monkeys fed a high-cholesterol diet.
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