Why the study?
Does captopril reduce aortic-lesion area in apolipoprotein E-deficient mice?
Population
Apolipoprotein (apo) E-deficient mice on chow diet
Comparison
Captopril 50 mg/kg/day vs Placebo
Design
Preclinical
Follow-up
12 weeks
Authors
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Should not change clinical practice; hypothesis-generating for ACE inhibition in atherosclerosis models.
Does captopril reduce aortic-lesion area in apolipoprotein E-deficient mice?
Captopril significantly attenuates the development of atherosclerosis in apo E-deficient mice, likely through inhibition of LDL oxidation.
Hayek et al. (1998) studied this question.
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