Why the study?
Do ACE inhibitors (enalapril or captopril) enhance tissue antioxidant defenses in mice?
Population
CF1 mice (4-mo-old females)
Comparison
Enalapril or captopril administered in water for… vs Water (control)
Design
Preclinical
Follow-up
11 weeks
Authors
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May enhance antioxidant defenses in rodent tissues; hypothesis-generating and should not yet change clinical practice.
Do ACE inhibitors (enalapril or captopril) enhance tissue antioxidant defenses in mice?
ACE inhibitors like enalapril and captopril may protect tissues from oxidative damage by enhancing enzymatic and nonenzymatic antioxidant defenses.
Cavanagh et al. (1997) studied this question.
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