Enhancement of Experimental Atherosclerosis by ACTH in the Dog.

S. Rosenfeld; Jessie Marmorston; H. Sobel; Anita White

doi:10.3181/00379727-103-25420

January 1, 1960Experimental Biology and Medicine

Enhancement of Experimental Atherosclerosis by ACTH in the Dog.

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Why the study?

Does ACTH-gel enhance atherosclerosis and lipid levels in dogs fed a high thiouracil and cholesterol diet?

Key Points

To determine whether ACTH pretreatment accelerates hyperlipidemia and vascular lesion development in dogs fed an atherogenic diet.
Administered 1 to 3 injections of 40 units of ACTH-gel to canines prior to initiating a high-cholesterol and thiouracil diet (N=10 in the ACTH group).
Assessed serum cholesterol and phospholipid concentrations and performed postmortem examinations to evaluate atherosclerotic lesion severity relative to diet-only controls.
ACTH pretreatment significantly exacerbated the elevation of serum cholesterol and phospholipid levels provoked by thiouracil and cholesterol feeding.
Paralytic strokes developed in 4 of 10 dogs (40%) pretreated with ACTH.
Autopsy demonstrated markedly more widespread and severe arterial atherosclerosis in ACTH-pretreated dogs than in dogs receiving the atherogenic diet alone.

Structured PICO

Does ACTH-gel enhance atherosclerosis and lipid levels in dogs fed a high thiouracil and cholesterol diet?

P

Population

Dogs fed a high thiouracil and cholesterol diet

I

Intervention

1 to 3 injections of 40 units of ACTH-gel

C

Comparator

High thiouracil and cholesterol diet alone

O

Outcome

Serum cholesterol and phospholipid levels, and severity of atherosclerosis at autopsysurrogate

ACTH pretreatment exacerbates hyperlipidemia and atherosclerosis in a canine model of diet-induced atherosclerosis.

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Implication

Supports caution with ACTH in dyslipidemic patients; leaves open translation to human atherosclerosis.

Abstract

One to 3 injections of 40 units of ACTH-gel significantly enhanced the elevated serum cholesterol and phospholipid levels produced by subsequent thiouracil and cholesterol feeding in the dog. This effect was associated with paralytic strokes in 4 of 10 dogs. Autopsy revealed markedly more widespread and more severe atherosclerosis in dogs pretreated with ACTH than in dogs who received only a high thiouracil and cholesterol diet.

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Cite This Study

Rosenfeld et al. (1960) studied this question.

synapsesocial.com/papers/6a82fab3114d53034e9c8381 https://doi.org/10.3181/00379727-103-25420

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Enhancement of Experimental Atherosclerosis by ACTH in the Dog.

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Enhancement of Experimental Atherosclerosis by ACTH in the Dog.

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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