Why the study?
Do cortisone, hydrocortisone, and corticotropin affect lipemia, glycemia, and atherogenesis in cholesterol-fed chicks?
Do cortisone, hydrocortisone, and corticotropin affect lipemia, glycemia, and atherogenesis in cholesterol-fed chicks?
In cholesterol-fed chicks, hydrocortisone and ACTH induce metabolic derangements without worsening atherogenesis, whereas cortisone intensifies atherogenesis and elevates blood pressure despite minimal metabolic effects.
Answers are grounded in this paper and cite their sources.
Animal data urge caution extrapolating steroid atherogenicity to patients; leaves open cortisone-specific mechanisms via hypertension.
Hydrocortisone markedly affected carbohydrate, protein, lipid and electrolyte metabolism of cholesterol-fed cockerels (intact, alloxanized and depancreatized). Despite steroid-induced diabetes and hyperadrenalism, associated with enhancement of hypercholesterolemic hyperlipemia, no hypertension or intensification of atherogenesis (aortic or coronary artery) supervened. Corticotropin (ACTH) produced similar effects. Cortisone was relatively inactive as a glycocorticoid in this avian species. Despite its apparently slight metabolic activity, however, it moderately elevated blood pressure and intensified atherogenesis.
No takes yet. Share an insight, caveat, or question.
Stamler et al. (1954) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: