Key result
Adolescent girls with anorexia nervosa exhibited significantly lower metaphyseal red marrow scores in the femur compared to healthy controls (0.64 vs 1.22, p=0.03).
Why the study?
Do adolescent girls with anorexia nervosa exhibit premature conversion of red to yellow bone marrow compared to healthy controls?
Population
40 adolescent girls (20 with anorexia nervosa and 20 healthy controls), mean age 16.2 +/- 1.6 years
Comparison
Right knee magnetic resonance imaging on a 1.0 T… vs Healthy controls
Design
Case-control, Blinded radiologists visually assessed RM
Authors
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Suggests premature red-to-yellow marrow conversion in anorexia nervosa; leaves open effects on fracture risk and monitoring needs.
Case-Control (n=40)
Blinded
Do adolescent girls with anorexia nervosa exhibit premature conversion of red to yellow bone marrow compared to healthy controls?
Absolute Event Rate: 0.64% vs 1.22%
p-value: p=0.03
Adolescent girls with anorexia nervosa show MRI evidence of premature conversion of hematopoietic to fat cells in peripheral skeleton marrow.
Ecklund et al. (2009) conducted a case-control in Anorexia nervosa (n=40). Anorexia nervosa vs. Healthy controls was evaluated on Metaphyseal red marrow (RM) score in the femur (p=0.03). Adolescent girls with anorexia nervosa exhibited significantly lower metaphyseal red marrow scores in the femur compared to healthy controls (0.64 vs 1.22, p=0.03).
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