Key result
A genetic risk score of 18 SNPs was significantly associated with 24-hour ambulatory systolic-diastolic pressure regression index (β 0.34; 95% CI 0.16-0.31; p<0.01).
Why the study?
Are specific single nucleotide polymorphisms and genetic risk scores associated with ambulatory systolic-diastolic pressure regression index in hypertensive patients with CAD?
Observational (n=1,345)
Are specific single nucleotide polymorphisms and genetic risk scores associated with ambulatory systolic-diastolic pressure regression index in hypertensive patients with CAD?
Specific genetic polymorphisms and a cumulative genetic risk score are significantly associated with ambulatory systolic-diastolic pressure regression index in hypertensive patients with CAD.
Supports genetic studies of ambulatory BP patterns in CAD hypertension; hypothesis-generating and should not change practice.
OBJECTIVES: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiography. METHODS: A total of 1345 hypertensive subjects with CAD were included. SNPs were selected from genome-wide association studies. SNPs were reported to be associated with coronary artery disease risk. There were significant differences in 24 h and daytime and nighttime ASDPRIs for PHCTR1, LPA and ADAMTS7 polymorphisms. Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for ASDPRI. RESULTS: Analysis of covariance revealed a significant relationship between the PPAB2B (β - 0.85; 95 CI -1.85--0.16, p < 0.02), WDR12 (β - 1.31; 95 CI -2.19--0.43, p < 0.01) polymorphisms and nighttime ASDPRI dipping. Analysis of covariance revealed a significant relationship between GRS 18 and 24-h ASDPRI (β 0.34; 95 CI 0.16-0.31, p < 0.01). CONCLUSIONS: In conclusion, ADAMTS7 and LPA polymorphisms are related to 24-h ASDPRI but PPAB2B and WDR12 gene polymorphisms are associated with nighttime ASDPRI dipping. A total of 24-h ASDPRI is determined by GRS18.
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Wirtwein et al. (2017) conducted an observational in Hypertension with coronary artery disease (n=1,345). Single nucleotide polymorphisms (SNPs) and Genetic Risk Score (GRS18) was evaluated on 24-h Ambulatory systolic-diastolic pressure regression index (ASDPRI) (β 0.34, 95% CI 0.16-0.31, p=< 0.01). A genetic risk score of 18 SNPs was significantly associated with 24-hour ambulatory systolic-diastolic pressure regression index (β 0.34; 95% CI 0.16-0.31; p<0.01).
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