Key result
Upper tract urothelial carcinoma with squamous differentiation can lead to rare, aggressive, and treatment-resistant cardiac metastasis, as seen in a 62-year-old male who succumbed to cardiac failure.
Why the study?
Upper tract urothelial carcinoma accounts for 5-10% of urothelial malignancies and rarely metastasizes to distant sites such as the heart.
Case Report (n=1)
This case highlights the rare potential for upper tract urothelial carcinoma with squamous differentiation to metastasize to the heart, leading to fatal progressive cardiac failure.
Answers are grounded in this paper and cite their sources.
Alerts to rare cardiac metastasis in upper tract urothelial carcinoma with heart failure; hypothesis-generating and should not yet change practice.
Introduction: Upper tract urothelial carcinoma, accounting for 5-10% of urothelial malignancies, rarely metastasizes to distant sites such as the heart. Case Presentation: This report describes a rare case of cardiac metastasis in a 62-year-old male with a complex history of recurrent urothelial carcinoma. Initially diagnosed with bladder cancer in 1999, the patient underwent multiple resections and intravesical therapies, followed by cystectomy in 2012 due to refractory anaplastic tumors. A decade later, he developed right-sided hydronephrosis and hematuria, prompting a nephroureterectomy, which revealed papillary urothelial carcinoma with squamous differentiation (pT3pNxMx). Despite aggressive local management, cardiac metastasis involving the right ventricular myocardium was identified in 2023. Systemic chemotherapy yielded minimal response, and the patient eventually succumbed to progressive cardiac failure. Conclusion: Squamous differentiation in urothelial carcinoma predicts aggressive, treatment-resistant behavior. Delayed post-cystectomy recurrence supports the concept of field cancerization and necessitates lifelong surveillance. A rare cardiac metastasis confirms the hematogenous spread potential and underscores the need for improved adjuvant therapies.
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Al‐Bitar et al. (2025) conducted a case report in Upper tract urothelial carcinoma with cardiac metastasis (n=1). Upper tract urothelial carcinoma with squamous differentiation was evaluated. Upper tract urothelial carcinoma with squamous differentiation can lead to rare, aggressive, and treatment-resistant cardiac metastasis, as seen in a 62-year-old male who succumbed to cardiac failure.
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