Key result
Advanced urothelial bladder carcinoma manifests as rapidly fatal biatrial and biventricular cardiac metastases.
Case Report (n=1)
This case report highlights a rare presentation of urothelial bladder cancer with cardiac metastasis leading to rapid clinical deterioration.
May signal cardiac involvement in rapidly progressing bladder cancer; extends sparse case reports but should not yet change practice.
We report a case with a large muscle-invasive bladder TCC and cardiac and disseminated metastases. A 74-year-old man was referred to our department due to a decline in general health, associated with macroscopic hematuria for the past two months, in the context of urinary infection. CT imaging revealed a large bladder tumor with bilateral hydronephrosis, suspicion of peritoneal carcinomatosis, and locoregional lymphadenopathies suggesting secondary involvement. Histology of the bladder tumor confirmed the diagnosis of high-grade infiltrating urothelial carcinoma. The 18-FDG PET scan detected diffuse lymph node, hepatic, and bone metastases, as well as peritoneal carcinomatosis and metastases in the left ventricle and atrium. Chemotherapy was planned for our patient; unfortunately, the patient passed away rapidly due to renal and cardiac complications before treatment could begin.
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Bounouar et al. (2026) conducted a case report in Urothelial Bladder Cancer with Cardiac Metastasis (n=1). Transurethral resection of bladder tumor was evaluated. A 74-year-old man with high-grade urothelial bladder carcinoma presented with rare cardiac metastases to the left ventricle and atrium, and died rapidly before planned chemotherapy could begin.
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