Key result
Depression is a significant shared risk factor for cognitive impairment, Alzheimer disease, and cardiovascular disease, with multiple depressive episodes increasing the risk of dementia.
This review highlights depression as a significant, shared risk factor for both cognitive impairment and vascular disease, including stroke.
Depression has been linked to cardiovascular disease and cognitive impairment, including Alzheimer disease, but the exact nature of the relationship is poorly understood. Although depression seems to progress little after the onset of Alzheimer disease, depression in earlier life increases the risk of dementia and cognitive impairment many years in the future. Depression is also associated with reduced vascular function and is a poorly recognized but significant risk factor for stroke.
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Dylan Wint (2011) conducted a review in Depression, cardiovascular disease, and Alzheimer disease. Depression vs. No depression was evaluated. Depression is a significant shared risk factor for cognitive impairment, Alzheimer disease, and cardiovascular disease, with multiple depressive episodes increasing the risk of dementia.
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