Key result
Pre-eclampsia was associated with a 15% incidence of thrombocytopenia, 2.5% incidence of possible platelet dysfunction, and 21% incidence of fibrinolysis.
Why the study?
What is the incidence of thrombocytopenia and platelet functional defects in pre-eclamptic patients?
Observational (n=40)
What is the incidence of thrombocytopenia and platelet functional defects in pre-eclamptic patients?
In pre-eclamptic patients, thrombocytopenia occurs in 15%, and a platelet count is essential before regional blockade, with bleeding time indicated if counts are 50-100 x 10^9/l.
May warrant platelet assessment before neuraxial anesthesia in pre-eclampsia; leaves open the utility of functional assays in larger cohorts.
A prospective, observational study of forty pre-eclamptic patients was conducted to confirm or refute reports of a platelet functional defect superimposed on the consumptive thrombocytopenia of pre-eclampsia. Investigations included a platelet count, in vivo platelet function as assessed by a Duke bleeding time, and in vitro platelet function as assessed by thromboxane B2 and Platelet Factor 3 (PF 3). The overall incidence of thrombocytopenia was 15%. Prolonged bleeding time and slightly decreased availability of PF 3 (evidence of possible platelet dysfunction) was present in 2.5% of patients while 21% had evidence of fibrinolysis with an elevated monoclonal D-dimer. In the assessment of suitability for regional blockade, a platelet count is essential. If the platelet count is between 50 and 100 x 10(9)/l a bleeding time is indicated.
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Schindler et al. (1990) conducted an observational in Pre-eclampsia (n=40). Pre-eclampsia was evaluated on Incidence of thrombocytopenia. Pre-eclampsia was associated with a 15% incidence of thrombocytopenia, 2.5% incidence of possible platelet dysfunction, and 21% incidence of fibrinolysis.
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