Key result
Uncomplicated type 1 diabetes was associated with significantly higher urinary ACE2 activity and protein levels during clamped euglycemia compared with normoglycemic controls (p < 0.0001).
Why the study?
Are urinary ACE2 activity and protein levels elevated in patients with uncomplicated type 1 diabetes compared to healthy controls, and how do they respond to hyperglycemia?
Observational (n=79)
Are urinary ACE2 activity and protein levels elevated in patients with uncomplicated type 1 diabetes compared to healthy controls, and how do they respond to hyperglycemia?
p-value: p=<0.0001
Urinary ACE2 activity and protein expression are increased in early, uncomplicated type 1 diabetes, suggesting a potential early biomarker or functional role prior to clinical complications.
Elevated urinary ACE2 in uncomplicated type 1 diabetes supports early biomarker investigation; hypothesis-generating for hyperglycemia response and outcomes.
Angiotensin-converting enzyme 2 (ACE2) is expressed in the kidney and may be renoprotective. We determined whether urinary ACE2 enzyme activity and protein levels (ELISA), as well as angiotensinogen and ACE, are elevated during clamped euglycemia (4-6 mmol·L(-1)) in patients with uncomplicated type 1 diabetes (T1D, n = 58) compared with normoglycemic controls (n = 21). We also measured the effect of clamped hyperglycemia (9-11 mmol·L(-1)) on each urinary factor in T1D patients. Urinary ACE2 activity and protein levels were higher during clamped euglycemia in T1D compared with the controls (p < 0.0001). In contrast, urinary angiotensinogen levels (p = 0.27) and ACE excretion (p = 0.68) did not differ. In response to clamped hyperglycemia in T1D, urinary ACE2 protein decreased (p < 0.0001), whereas urinary ACE2 activity as well as angiotensinogen and ACE levels remained unchanged. Urinary ACE2 activity and protein expression are increased in T1D patients prior to the onset of clinical complications. Further work is required to determine the functional role of urinary ACE2 in early T1D.
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Cherney et al. (2014) conducted an observational in Uncomplicated type 1 diabetes (n=79). Type 1 diabetes vs. Normoglycemic controls was evaluated on Urinary ACE2 enzyme activity and protein levels during clamped euglycemia (p=<0.0001). Uncomplicated type 1 diabetes was associated with significantly higher urinary ACE2 activity and protein levels during clamped euglycemia compared with normoglycemic controls (p < 0.0001).
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