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December 16, 2011Journal of Hypertension

Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications

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Population

859 patients with type 1 diabetes from the Finnish Diabetic Nephropathy study and 204 healthy controls…

Design

Cross-sectional

Authors

ASAino Soro‐PaavonenUniversity of HelsinkiDGDaniel GordinJoslin Diabetes CenterCFCarol ForsblomUniversity of Helsinki

Discussion

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Implication

Supports compensatory ACE2 role in T1D complications; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
859 patients with type 1 diabetes (T1D) from the Finnish Diabetic Nephropathy (FinnDiane) study and 204 healthy controls. Pulse-wave analysis performed in 319 T1D patients and 114 controls.
O
Outcome
Quantitative ACE2 activity in serumsurrogate

Circulating ACE2 activity is elevated in type 1 diabetes patients with microvascular or macrovascular complications, suggesting a compensatory role in vascular and renal regulation.

Cite This Study

Soro‐Paavonen et al. (2011) studied this question.

synapsesocial.com/papers/6a71eaa578a11c550e0bda3bhttps://doi.org/10.1097/hjh.0b013e32834f04b6
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