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January 13, 2025Indian Journal of Physiology and PharmacologyOpen Access

Increased angiotensin converting enzyme (ACE2) level is associated with the cardiovascular risk in diabetes

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Why the study?

The study aimed to investigate the association between increased ACE2 levels and cardiovascular risk in patients with type 2 diabetes mellitus, particularly those with cardiovascular disease.

Are increased ACE2 levels associated with cardiovascular risk in patients with type 2 diabetes mellitus?

Population

3 groups of 87 individuals each (controls, diabetes, and diabetes with heart disease)

Comparison

Controls vs diabetes vs diabetes with heart disease

Design

Cross-sectional study

Authors

GNG. NaveenaSRM Institute of Science and TechnologyMSMeera ShivasekarACS Medical College and HospitalVVVM VinodhiniSRM Institute of Science and Technology

Discussion

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Member takes

Overview

Higher ACE2 may flag CV risk in T2DM; hypothesis-generating and requires prospective validation before any clinical role.

Structured PICO

Are increased ACE2 levels associated with cardiovascular risk in patients with type 2 diabetes mellitus?

P
Population
261 individuals divided into 3 groups (n=87 each): healthy controls (Group I), patients with type 2 diabetes mellitus (Group II), and patients with type 2 diabetes mellitus and heart disease (Group III).
O
Outcome
Serum ACE, ACE2, oxidized-low-density lipoprotein (ox-LDL), highly sensitive c-reactive protein (hs-CRP), and lipid levelssurrogate

Increased ACE2 levels are strongly associated with inflammatory and lipid biomarkers in patients with type 2 diabetes and heart disease, suggesting its potential utility for independent cardiovascular risk assessment.

Cite This Study

Naveena et al. (2025) studied this question.

synapsesocial.com/papers/6a911df331a95240343e98f3https://doi.org/10.25259/ijpp_288_2024
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