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July 1, 2025Journal of the Renin-Angiotensin-Aldosterone System

Association of ACE & ACE2 with inflammatory markers studied in T2DM patients with & without CHD

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Key result

T2DM and CHD are linked to elevated ACE, ACE2, IL-6, and TNF-α versus healthy controls.

  • P<0.01
  • n=261

Why the study?

The study aimed to evaluate ACE, ACE2, and inflammatory mediators that have emerged as significant indicators of cardiovascular risk and mortality.

Are plasma ACE, ACE2, and inflammatory markers associated with coronary heart disease in patients with type 2 diabetes mellitus?

Population

261 participants across healthy controls, T2DM, and T2DM with CHD

Comparison

Healthy controls vs T2DM vs T2DM with CHD

Design

Observational cross-sectional study

Authors

GNG. NaveenaMSMeera ShivasekarVVV.M. Vinodhini

Discussion

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Overview

Elevated ACE, ACE2, and inflammatory markers associate with CHD in T2DM; hypothesis-generating for risk stratification.

Study Design

Type

Observational (n=261)

Structured PICO

Are plasma ACE, ACE2, and inflammatory markers associated with coronary heart disease in patients with type 2 diabetes mellitus?

P
Population
261 participants stratified into three groups (n=87 each): healthy controls, Type 2 Diabetes Mellitus (T2DM), and Type 2 Diabetes Mellitus with Coronary Heart Disease (CHD).
C
Comparator
Healthy controls and T2DM without CHD
O
Outcome
Plasma concentrations of ACE, ACE2, Interleukin-6 (IL-6), and Tumor Necrosis Factor -α (TNF-α)surrogate

Main Result

p-value: p=<0.01

Plasma ACE, ACE2, and inflammatory mediators are significantly elevated in T2DM patients with CHD, suggesting their potential utility in cardiovascular risk assessment.

Cite This Study

Naveena et al. (2025) conducted an observational in Type 2 Diabetes Mellitus with and without Coronary Heart Disease (n=261). Circulating concentrations of ACE, ACE2, ACE/ACE2 ratio, IL-6, and TNF-α were significantly elevated in patients with T2DM and CHD compared to healthy controls (P<0.01).

synapsesocial.com/papers/6a0cd46ea4d785ea816261dehttps://doi.org/10.1177/14703203251386326
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased angiotensin converting enzyme (ACE2) level is associated with the cardiovascular risk in diabetes2025
  2. 2Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications2011 · 215 citations
  3. 3ANGIOPOETIN-2 LEVELS IN PATIENTS WITH COMORBIDITY OF CORONARY ARTERY DISEASE AND TYPE 2 DIABETES MELLITUS2025
  4. 4Insulin resistance, blood glucose and inflammatory cytokine levels are risk factors for cardiovascular events in diabetic patients complicated with coronary heart disease2017 · 33 citations
  5. 5Angiopoietin-2 as a biomarker of non-ST-segment elevation myocardial infarction in patients with or without type 2 diabetes2019 · 5 citations