Key result
Patients with comorbid coronary artery disease and type 2 diabetes mellitus had significantly higher blood levels of angiopoietin-2 (median 2142.95 pg/ml) compared to those with CAD without diabetes (1762.07 pg/ml).
Why the study?
Comorbid coronary artery disease and type 2 diabetes mellitus worsen cardiovascular outcomes, but the role and clinical associations of the angiogenesis activator angiopoietin-2 in CAD patients with versus without diabetes remained to be examined.
Population
61 patients aged 40 to 72 years with CAD and stable angina functional class II
Comparison
CAD with moderate type 2 diabetes mellitus vs CAD without diabetes mellitus
Authors
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Comorbid CHD and T2DM heighten complication risks; Level 5 data leave optimal strategies open for prospective trials.
Cross-Sectional (n=83)
No
Absolute Event Rate: 2142.95% vs 1762.07%
p-value: p=<0.001
Angiopoietin-2 levels are significantly elevated in patients with both coronary artery disease and type 2 diabetes mellitus, suggesting its potential utility as a biomarker for assessing cardiovascular risk and inflammatory burden in this comorbid population.
Lytvynova et al. (2025) conducted a cross-sectional in Coronary Artery Disease and Type 2 Diabetes Mellitus (n=83). Type 2 Diabetes Mellitus vs. Coronary Artery Disease without Type 2 Diabetes Mellitus was evaluated on Blood levels of Angiopoietin-2 (Ang-2) in pg/ml (p=<0.001). Patients with comorbid coronary artery disease and type 2 diabetes mellitus had significantly higher blood levels of angiopoietin-2 (median 2142.95 pg/ml) compared to those with CAD without diabetes (1762.07 pg/ml).
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